| Structural highlights
Function
CXCL6_HUMAN Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).[1] [2] [3] [4]
References
- ↑ Linge HM, Collin M, Nordenfelt P, Mörgelin M, Malmsten M, Egesten A. The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial. Antimicrob Agents Chemother. 2008 Jul;52(7):2599-607. PMID:18443119 doi:10.1128/AAC.00028-08
- ↑ Proost P, Wuyts A, Conings R, Lenaerts JP, Billiau A, Opdenakker G, Van Damme J. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. Biochemistry. 1993 Sep 28;32(38):10170-7. PMID:8399143 doi:10.1021/bi00089a037
- ↑ Proost P, De Wolf-Peeters C, Conings R, Opdenakker G, Billiau A, Van Damme J. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. J Immunol. 1993 Feb 1;150(3):1000-10 PMID:8423327
- ↑ Froyen G, Proost P, Ronsse I, Mitera T, Haelens A, Wuyts A, Opdenakker G, Van Damme J, Billiau A. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs. Eur J Biochem. 1997 Feb 1;243(3):762-9. PMID:9057843 doi:10.1111/j.1432-1033.1997.00762.x
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