8yd0

CryoEM structure of M. tuberculosis ClpXP1P2 complex bound to bortezomib

spinqualitylabelsall models 8yd0, resolution 2.24Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8yd0 is a 20 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.24Å Ligands: ADP, ATP, BO2, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CLPX_MYCTU ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpP2. Does not seem to act on anti-sigma-L factor RslA.[HAMAP-Rule:MF_00175]

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