8yh2

A3R-Gi complex bound to adenosine

spinqualitylabelsall models 8yh2, resolution 3.27Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8yh2 is a 5 chain structure with sequence from Homo sapiens, Human orthopneumovirus, Influenza A virus (A/Victoria/3/1975(H3N2)), Mus musculus, Ovis aries and Rattus rattus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.27Å Ligands: ADN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function W5QED6_SHEEP Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.[RuleBase:RU201114]A0A5P9VSM6_HRSV HEMA_I75A3 Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

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