8ykd

Cryo-EM structure of ADGRG2-Gs complex with NTF nanobody

spinqualitylabelsall models 8ykd, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ykd is a 6 chain structure with sequence from Spodoptera. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.9Å Ligands: AND Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function AGRG2_MOUSE Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione (PubMed:35982227). Involved in a signal transduction pathway controlling epididymal function and male fertility (PubMed:15367682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:35982227). ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:35982227). Also able to couple with G(q) G proteins in vitro (PubMed:35982227). May regulate fluid exchange within epididymis (PubMed:15367682).

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