Structural highlights
Function
PRT1_ARATH E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Functions in the N-end rule pathway of protein degradation, where it specifically recognizes and ubiquitinates proteins with a N-terminal bulky aromatic amino acid (Phe). Does not act on aliphatic hydrophobic and basic N-terminal residues (Arg or Leu) containing proteins.[1] [2] [3] [4]
References
- ↑ Bachmair A, Becker F, Schell J. Use of a reporter transgene to generate arabidopsis mutants in ubiquitin-dependent protein degradation. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):418-21. PMID:11607348 doi:10.1073/pnas.90.2.418
- ↑ Stary S, Yin XJ, Potuschak T, Schlögelhofer P, Nizhynska V, Bachmair A. PRT1 of Arabidopsis is a ubiquitin protein ligase of the plant N-end rule pathway with specificity for aromatic amino-terminal residues. Plant Physiol. 2003 Nov;133(3):1360-6. PMID:14551326 doi:10.1104/pp.103.029272
- ↑ Garzon M, Eifler K, Faust A, Scheel H, Hofmann K, Koncz C, Yephremov A, Bachmair A. PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus. FEBS Lett. 2007 Jul 10;581(17):3189-96. doi: 10.1016/j.febslet.2007.06.005. Epub , 2007 Jun 12. PMID:17572409 doi:https://dx.doi.org/10.1016/j.febslet.2007.06.005
- ↑ Potuschak T, Stary S, Schlögelhofer P, Becker F, Nejinskaia V, Bachmair A. PRT1 of Arabidopsis thaliana encodes a component of the plant N-end rule pathway. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7904-8. PMID:9653113 doi:10.1073/pnas.95.14.7904
