8zkp

Cryo-EM structure of the efflux transporter MmpL5/MmpS5 from Mycobacterium tuberculosis, C3 symmetry

spinqualitylabelsall models 8zkp, resolution 2.64Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8zkp is a 9 chain structure with sequence from Mycobacterium tuberculosis H37Rv and Mycolicibacterium smegmatis MC2 155. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.64Å Ligands: CDL, PEV, PN7 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MMPL5_MYCTU Part of an export system, which is required for biosynthesis and secretion of siderophores. Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.

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