8zt5

Structure of calcium preference ATP-gated channel P2X1 in the Desensitized state 2 in the presence of 1mM Calcium ion

spinqualitylabelsall models 8zt5, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8zt5 is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.35Å Ligands: ATP, CA, MG, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function P2RX1_MOUSE ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (By similarity). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility, bladder contraction and platelet aggregation (PubMed:10638758, PubMed:11090125, PubMed:19635923, PubMed:25150292). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (PubMed:10638758). In addition, contributes to smooth muscle contractions of the urinary bladder (PubMed:11090125). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (PubMed:25150292). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923).[UniProtKB:P51575]

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