8zwc

Cryo-EM Structure of the BLOC-3 complex

spinqualitylabelsall models 8zwc, resolution 3.19Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8zwc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.19Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease HPS1_HUMAN Hermansky-Pudlak syndrome due to BLOC-3 deficiency. The disease is caused by variants affecting the gene represented in this entry. Function HPS1_HUMAN Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).

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