9b7d

Structure of ThsB-Tad3 complex

spinqualitylabelsall models 9b7d, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9b7d is a 4 chain structure with sequence from Bacillus cereus and Metagenome. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.8Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function THSB1_BACCS TIR-like domain-containing component of the Thoeris antiviral defense system, composed of ThsA and ThsB. Expression of ThsA and ThsB in B.subtilis (strain BEST7003) confers resistance to phages SBSphiC, SBSphiJ and SPO1 (PubMed:29371424, PubMed:34853457). Phage infection activates this protein so that 30 to 45 minutes post-infection with phage SPO1 it generates a signal molecule that in turn activates the NAD(+) hydrolase activity of ThsA. The signal is similar to cyclic ADP-D-ribose, but how it differs is unknown (PubMed:34853457). In vitro purified (but unactivated) ThsB has no NAD(+) hydrolyzing activity, no activity on AMP, CMP, GMP or UMP, does not alter the activity of ThsA, does not bind DNA (PubMed:32499527). Hydrolyzes NAD(+) to make a cyclic ADP-D-ribose (cADPR) signaling molecule; might make 3'cADPR (By similarity).[UniProtKB:J8CSK2]

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