9b8u

Crystal structure of CRX-Ret4 oligonucleotide complex

spinqualitylabelsall models 9b8u, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9b8u is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.9Å Ligands: CAC, GOL, K, MPD, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease CRX_HUMAN Leber congenital amaurosis;Retinitis pigmentosa;Cone rod dystrophy. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Function CRX_HUMAN Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.

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