9c24

Fab F946 in complex with OspCB

spinqualitylabelsall models 9c24, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9c24 is a 6 chain structure with sequence from Borreliella burgdorferi B31 and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.8Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function OSPC2_BORBG Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.[UniProtKB:Q07337]

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