9cro

Post-targeting aCascade Type IA CRISPR-Cas Surveillance Complexes

spinqualitylabelsall models 9cro, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9cro is a 15 chain structure with sequence from Saccharolobus solfataricus and Saccharolobus solfataricus P2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.5Å Ligands: TRS Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CSA5B_SACS2 CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In strain P2 toxic when expressed in vivo in the absence of CRISPR loci A-D (strain P2 contains 6 CRISPR loci in all). It causes strong growth inhibition, a significant proportion of cells have degraded or no DNA by 20-24 post-induction (PubMed:25277654).

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