Structural highlights
Function
SERF2_HUMAN Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (PubMed:20723760).[1]
References
- ↑ van Ham TJ, Holmberg MA, van der Goot AT, Teuling E, Garcia-Arencibia M, Kim HE, Du D, Thijssen KL, Wiersma M, Burggraaff R, van Bergeijk P, van Rheenen J, Jerre van Veluw G, Hofstra RM, Rubinsztein DC, Nollen EA. Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. Cell. 2010 Aug 20;142(4):601-12. PMID:20723760 doi:10.1016/j.cell.2010.07.020
