9ect

Crystal Structure of the Gemella haemolysans Immunoglobulin A1 Protease Trypsin-Like Domain

spinqualitylabelsall models 9ect, resolution 1.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9ect is a 2 chain structure with sequence from Gemella haemolysans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.75Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C5NYF3_9BACL Publication Abstract from PubMed Immunoglobulin A (IgA) proteases are a group of bacterial-derived enzymes that selectivity hydrolyze human IgA in the hinge region that is unique to this immunoglobulin. Several IgA protease (IgAP) families have evolved this ability using both metalloprotease and serine protease chemical mechanisms. One family of metal-dependent IgAPs is the M26 family. This family can be grouped into two subfamilies based upon the presence or absence of a trypsin-like domain found N-terminal to the IgAP domain. The role of this domain in IgAP structure and function is poorly understood. Here, we present the first structural characterization of an M26 IgAP trypsin-like domain from Gemella haemolysans (GhTrp). These structural data demonstrate that the GhTrp domain possesses a trypsin-like fold but contains significant deviations in the surface-loop structure that is known to be coupled to protease selectivity. The lack of observable catalytic function coupled with the structural data suggest that this domain may exist in a pro-enzyme-like state that can potentially be activated when the domain is N-terminally proteolytically excised from the larger M26 IgAP structure. The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain.,Tran N, Redzic JS, Eisenmesser EZ, Holyoak T Acta Crystallogr F Struct Biol Commun. 2025 Apr 1. doi: , 10.1107/S2053230X25001219. PMID:40019192 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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