9eho

Octopus ribosome, hybrid 80S

spinqualitylabelsall models 9eho, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9eho is a 10 chain structure with sequence from Octopus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.1Å Ligands: MG, N, SPD, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A6P7SHL5_9MOLL Publication Abstract from PubMed Much of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and sophisticated behaviors that rival vertebrates, but via an entirely divergent evolutionary history. Here, we serendipitously discovered that octopus ribosomes contain a structural break in the core ribosomal RNA that is unique among all animals. This break site enhances translation fidelity to reduce miscoding and subsequent protein aggregation, even when engineered into evolutionarily distant bacterial ribosomes. Furthermore, high fidelity translation by octopus ribosomes supports proteomic stability during extensive RNA editing observed in cephalopods, suggesting synergy between distinct non-canonical modes of gene regulation. This adaptation emerged in recently derived octopuses with expanded nervous systems, thereby revealing a mechanism that could broadly support the evolution of novel organismal traits. Evolution of a core ribosomal innovation in octopus.,Mitra R, Han R, Scott TJ, Grearson AG, Willi JA, Liu CG, Kim H, Jewett MC, Bellono NW, Lee AS bioRxiv [Preprint]. 2026 Jun 26:2026.06.25.734654. doi: , 10.64898/2026.06.25.734654. PMID:42395388 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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