9erv

Structure of Salmonella CapRel bound to Bas11 Gp54

spinqualitylabelsall models 9erv, resolution 2.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9erv is a 2 chain structure with sequence from Bacteriophage sp. and Salmonella. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.253Å Ligands: ATP, GOL, MG, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A1B0VBT5_9CAUD Publication Abstract from PubMed Eukaryotic innate immune systems use pattern recognition receptors to sense infection by detecting pathogen-associated molecular patterns, which then triggers an immune response. Bacteria have similarly evolved immunity proteins that sense certain components of their viral predators, known as bacteriophages(1-6). Although different immunity proteins can recognize different phage-encoded triggers, individual bacterial immunity proteins have been found to sense only a single trigger during infection, suggesting a one-to-one relationship between bacterial pattern recognition receptors and their ligands(7-11). Here we demonstrate that the antiphage defence protein CapRel(SJ46) in Escherichia coli can directly bind and sense two completely unrelated and structurally different proteins using the same sensory domain, with overlapping but distinct interfaces. Our results highlight the notable versatility of an immune sensory domain, which may be a common property of antiphage defence systems that enables them to keep pace with their rapidly evolving viral predators. We found that Bas11 phages harbour both trigger proteins that are sensed by CapRel(SJ46) during infection, and we demonstrate that such phages can fully evade CapRel(SJ46) defence only when both triggers are mutated. Our work shows how a bacterial immune system that senses more than one trigger can help prevent phages from easily escaping detection, and it may allow the detection of a broader range of phages. More generally, our findings illustrate unexpected multifactorial sensing by bacterial defence systems and complex coevolutionary relationships between them and their phage-encoded triggers. A bacterial immunity protein directly senses two disparate phage proteins.,Zhang T, Cepauskas A, Nadieina A, Thureau A, Coppieters 't Wallant K, Martens C, Lim DC, Garcia-Pino A, Laub MT Nature. 2024 Oct 16. doi: 10.1038/s41586-024-08039-y. PMID:39415022 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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