9fo1

Family S1_16 sulfatase from metagenomic dataset AMOR

spinqualitylabelsall models 9fo1, resolution 3.11Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9fo1 is a 1 chain structure with sequence from Bryobacteraceae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.11Å Ligands: CA, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Carrageenans are sulfated polysaccharides found in the cell wall of certain red seaweeds. They are widely used in the food industry for their gelling and stabilizing properties. In nature, carrageenans undergo enzymatic modification and degradation by marine organisms. Characterizing these enzymes is crucial for understanding carrageenan utilization and may eventually enable the development of targeted processes to modify carrageenans for industrial applications. In our study, we characterized a kappa-carrageenan sulfatase, AMOR_S1_16A, belonging to the sulfatase S1_16 subfamily, which selectively desulfates the nonreducing end galactoses of kappa-carrageenan oligomers in an exomode. Notably, AMOR_S1_16A represents the first kappa-carrageenan sulfatase within the S1_16 subfamily and exhibits a novel enzymatic activity. This study provides further understanding of the substrate specificity and characteristics of the S1_16 subfamily. Moreover, this research highlights that many processes and enzymes remain to be discovered to fully understand carrageenan utilization pathways and to develop enzymatic processes for carrageenan modification and processing. Identification and Characterization of a New Thermophilic kappa-Carrageenan Sulfatase.,Rhein-Knudsen N, Reyes-Weiss DS, Klau LJ, Jeudy A, Roret T, Stokke R, Eijsink VGH, Aachmann FL, Czjzek M, Horn SJ J Agric Food Chem. 2025 Jan 11. doi: 10.1021/acs.jafc.4c09751. PMID:39797788 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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