9gdm

Solution structure of a silver ion mediated DNA duplex with universal 7-deazapurine substitutions

spinqualitylabelsall models 9gdm Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9gdm is a 2 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 10 models Ligands: 7DA, 7GU, AG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The challenge of transforming organized DNA structures into their metallized counterparts persists in the scientific field. In this context, utilizing DNA molecules modified with 7-deazapurine, provides a transformative solution. In this study, we present the solution structure of a DNA duplex that can be transformed into its metallized equivalent while retaining the natural base pairing arrangement through the creation of silver-modified Watson-Crick base pairs. Unlike previously documented X-ray structures, our research demonstrates the feasibility of preserving the intrinsic DNA self-assembly while incorporating Ag(I) into the double helix, illustrating that the binding of silver does not disrupt the canonical base-pairing organization. Moreover, in our case, the uninterrupted Ag(I) chain deviates from forming conventional straight linear chains; instead, it adheres to a helical arrangement dictated by the underlying DNA structure. This research challenges conventional assumptions and opens the door to precisely design structures based on the organization of highly stable Ag-DNA assemblies. Unveiling the solution structure of a DNA duplex with continuous silver-modified Watson-Crick base pairs.,Javornik U, Perez-Romero A, Lopez-Chamorro C, Smith RM, Dobado JA, Palacios O, Bera MK, Nyman M, Plavec J, Galindo MA Nat Commun. 2024 Sep 5;15(1):7763. doi: 10.1038/s41467-024-51876-8. PMID:39237564 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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