9ggg

Cryo-EM structure of Thromboxane A2 receptor-miniGq Protein Complex bound to I-BOP

spinqualitylabelsall models 9ggg, resolution 3.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9ggg is a 5 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.25Å Ligands: A1IK0, CLR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease TA2R_HUMAN Bleeding diathesis due to thromboxane synthesis deficiency. Disease susceptibility is associated with variants affecting the gene represented in this entry. Function TA2R_HUMAN Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Activates adenylyl cyclase. Inhibits adenylyl cyclase.

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