Structural highlights
9gjl is a 2 chain structure with sequence from Entamoeba histolytica HM-1:IMSS. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | Electron Microscopy, Resolution 3.4Å |
| Ligands: | BMA, GAL, MAN, NAG, NDG, PRD_900019 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
HGL1_ENTH1 Lectin which binds galactose and N-acetyl-D-galactosamine of host glycoproteins and thus mediates adhesion to host cells (Probable). Mediates adherence to host colonic mucins, an essential step for pathogenic tissue invasion (Probable).[1]
References
- ↑ Petri WA Jr, Haque R, Mann BJ. The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica. Annu Rev Microbiol. 2002;56:39-64. PMID:12142490 doi:10.1146/annurev.micro.56.012302.160959
