9gsw

Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4d

spinqualitylabelsall models 9gsw, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9gsw is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.95Å Ligands: A1IO5, BMA, CL, CSO, EDO, FUC, GOL, MAN, NAG, PEG, PGE, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease LYAG_HUMAN Glycogen storage disease due to acid maltase deficiency, infantile onset;Glycogen storage disease due to acid maltase deficiency, juvenile onset;Glycogen storage disease due to acid maltase deficiency, adult onset. The disease is caused by mutations affecting the gene represented in this entry. Function LYAG_HUMAN Essential for the degradation of glygogen to glucose in lysosomes.

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