Structural highlights
Function
E27_NPVAC Acts as a cyclin-like protein and plays a role in the modulation of host cell cycle. May promote G2/S arrest by interacting with host mus209/PCNA, cdc2 and cdk6. The cell cycle arrest is characterized by an intact nuclear envelope, concomitant with sustained activity of host cdc2. However, viral DNA replication still occurs in the arrested cells.[1]
References
- ↑ Belyavskyi M, Braunagel SC, Summers MD. The structural protein ODV-EC27 of Autographa californica nucleopolyhedrovirus is a multifunctional viral cyclin. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11205-10. PMID:9736714 doi:10.1073/pnas.95.19.11205
