9hb7

Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor AG-01-128

spinqualitylabelsall models 9hb7, resolution 2.96Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9hb7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.9551876Å Ligands: FE, JCR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease TPH2_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders. Function TPH2_HUMAN

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