9hjt
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Structure of Zincore (SEPHS1:QRICH1) binding to ZFP91 on DNA
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Structural highlights
FunctionZFP91_HUMAN Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.[1] [2] References
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This page was last modified 16:20, 9 July 2025.