9hm7
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Cryo-EM structure of apo human separase with the mutation C2029S
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Structural highlights
FunctionESPL1_HUMAN Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.[1] [2] References
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This page was last modified 10:25, 3 September 2025.