9hw7

Variant Y432F of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in resting state at 1.3 Angstrom resolution

spinqualitylabelsall models 9hw7, resolution 1.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9hw7 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.3Å Ligands: CSS, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease UMPS_HUMAN Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies. Function UMPS_HUMAN

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