9i5s

Solution structure of an intramolecular anti-parallel G-quadruplex with a 5'-end overhang.

spinqualitylabelsall models 9i5s Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9i5s is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 10 models Ligands: BGM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed G-quadruplex structures formed by human telomeric sequences are highly sensitive to subtle sequence variations and local environment. While most structural studies have focused on sequences containing four uninterrupted G-tracts, the structural consequences of splitting a G-tract remain unexplored. Here, we present the NMR solution structure of a human telomeric sequence with the first G-tract split. The structure adopts an antiparallel topology with a disordered GTT segment at the 5'-end. This conformation is preferentially formed at a biologically relevant double-strand/single-strand DNA junction. These findings broaden our understanding of the structural diversity of human telomeric G-quadruplexes. An antiparallel G-quadruplex structure with a 5'-end overhang forms predominantly at the human telomeric ds-ss DNA junction.,Avendano Avila C, Heddi B Chem Commun (Camb). 2025 Nov 7;61(90):17661-17664. doi: 10.1039/d5cc03633j. PMID:41099088 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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