| Structural highlights
Function
TEN3_MOUSE Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:17478416, PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022, PubMed:29414938). Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (PubMed:29414938). Promotes homophilic adhesion in a splicing isoform-dependent manner: most isoforms (isoform-type A and type-B) can mediate homophilic interaction (PubMed:29414938). Promotes axon guidance (PubMed:23028443). Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway (PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022). Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) (PubMed:17803360, PubMed:23028443). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes (PubMed:20636325).[1] [2] [3] [4] [5] [6] [7]
References
- ↑ Leamey CA, Glendining KA, Kreiman G, Kang ND, Wang KH, Fassler R, Sawatari A, Tonegawa S, Sur M. Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways. Cereb Cortex. 2008 Jan;18(1):53-66. PMID:17478416 doi:10.1093/cercor/bhm031
- ↑ Leamey CA, Merlin S, Lattouf P, Sawatari A, Zhou X, Demel N, Glendining KA, Oohashi T, Sur M, Fässler R. Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol. 2007 Sep;5(9):e241. PMID:17803360 doi:10.1371/journal.pbio.0050241
- ↑ Murakami T, Fukunaga T, Takeshita N, Hiratsuka K, Abiko Y, Yamashiro T, Takano-Yamamoto T. Expression of Ten-m/Odz3 in the fibrous layer of mandibular condylar cartilage during postnatal growth in mice. J Anat. 2010 Sep;217(3):236-44. PMID:20636325 doi:10.1111/j.1469-7580.2010.01267.x
- ↑ Merlin S, Horng S, Marotte LR, Sur M, Sawatari A, Leamey CA. Deletion of Ten-m3 induces the formation of eye dominance domains in mouse visual cortex. Cereb Cortex. 2013 Apr;23(4):763-74. PMID:22499796 doi:10.1093/cercor/bhs030
- ↑ Dharmaratne N, Glendining KA, Young TR, Tran H, Sawatari A, Leamey CA. Ten-m3 is required for the development of topography in the ipsilateral retinocollicular pathway. PLoS One. 2012;7(9):e43083. PMID:23028443 doi:10.1371/journal.pone.0043083
- ↑ Tran H, Sawatari A, Leamey CA. The glycoprotein Ten-m3 mediates topography and patterning of thalamostriatal projections from the parafascicular nucleus in mice. Eur J Neurosci. 2015 Jan;41(1):55-68. PMID:25406022 doi:10.1111/ejn.12767
- ↑ Berns DS, DeNardo LA, Pederick DT, Luo L. Teneurin-3 controls topographic circuit assembly in the hippocampus. Nature. 2018 Feb 15;554(7692):328-333. PMID:29414938 doi:10.1038/nature25463
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