9ijw

Serine protease inhibitor HCIQ2c1 from Heteractis crispa with TRPA1 mediated antinociceptive activity

spinqualitylabelsall models 9ijw Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9ijw is a 1 chain structure with sequence from Radianthus crispa. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 20 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function VKT2I_RADCR Serine protease inhibitor that also shows protective effect in a cytotoxicity model (PubMed:32144281). It binds to all proteases tested (trypsin (Ki=52 nM), alpha-chymotrypsin, cathepsin G, kallikrein, and human neutrophil elastase) (PubMed:32144281). It significantly increases neuroblastoma cell viability in an in vitro neurotoxicity model, being a consequence of an effective decrease of reactive oxygen species (ROS) level in the cells (PubMed:32144281, PubMed:35563513). It also seems to protect cells by inhibiting ATP-induced purinoceptor (P2RX7) activation (PubMed:35563513).

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