Structural highlights
9ivc is a 6 chain structure with sequence from Aureobasidium pullulans and Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | Electron Microscopy, Resolution 3.17Å |
| Ligands: | A1L3I, A1L3J, IIL, MEA, MVA |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
AUR1_YEAST Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.[1] [2] [3] [4]
References
- ↑ Levine TP, Wiggins CA, Munro S. Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. Mol Biol Cell. 2000 Jul;11(7):2267-81. PMID:10888667 doi:10.1091/mbc.11.7.2267
- ↑ Aeed PA, Young CL, Nagiec MM, Elhammer AP. Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A. Antimicrob Agents Chemother. 2009 Feb;53(2):496-504. PMID:19047657 doi:10.1128/AAC.00633-08
- ↑ Sato K, Noda Y, Yoda K. Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Mol Biol Cell. 2009 Oct;20(20):4444-57. PMID:19726565 doi:10.1091/mbc.e09-03-0235
- ↑ Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC. Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem. 1997 Apr 11;272(15):9809-17. PMID:9092515 doi:10.1074/jbc.272.15.9809
