| Structural highlights
Function
HIR2_YEAST Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during the cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10]
References
- ↑ Dimova D, Nackerdien Z, Furgeson S, Eguchi S, Osley MA. A role for transcriptional repressors in targeting the yeast Swi/Snf complex. Mol Cell. 1999 Jul;4(1):75-83. PMID:10445029 doi:10.1016/s1097-2765(00)80189-6
- ↑ Ng HH, Robert F, Young RA, Struhl K. Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Genes Dev. 2002 Apr 1;16(7):806-19. PMID:11937489 doi:10.1101/gad.978902
- ↑ Formosa T, Ruone S, Adams MD, Olsen AE, Eriksson P, Yu Y, Rhoades AR, Kaufman PD, Stillman DJ. Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics. 2002 Dec;162(4):1557-71. PMID:12524332
- ↑ Prochasson P, Florens L, Swanson SK, Washburn MP, Workman JL. The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev. 2005 Nov 1;19(21):2534-9. PMID:16264190 doi:10.1101/gad.1341105
- ↑ Green EM, Antczak AJ, Bailey AO, Franco AA, Wu KJ, Yates JR 3rd, Kaufman PD. Replication-independent histone deposition by the HIR complex and Asf1. Curr Biol. 2005 Nov 22;15(22):2044-9. PMID:16303565 doi:https://dx.doi.org/S0960-9822(05)01306-0
- ↑ Nourani A, Robert F, Winston F. Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae. Mol Cell Biol. 2006 Feb;26(4):1496-509. PMID:16449659 doi:10.1128/MCB.26.4.1496-1509.2006
- ↑ Sherwood PW, Tsang SV, Osley MA. Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Mol Cell Biol. 1993 Jan;13(1):28-38. PMID:8417331 doi:10.1128/mcb.13.1.28-38.1993
- ↑ Spector MS, Raff A, DeSilva H, Lee K, Osley MA. Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol. 1997 Feb;17(2):545-52. PMID:9001207 doi:10.1128/MCB.17.2.545
- ↑ Qian Z, Huang H, Hong JY, Burck CL, Johnston SD, Berman J, Carol A, Liebman SW. Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins. Mol Cell Biol. 1998 Aug;18(8):4783-92. PMID:9671488 doi:10.1128/MCB.18.8.4783
- ↑ Kaufman PD, Cohen JL, Osley MA. Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I. Mol Cell Biol. 1998 Aug;18(8):4793-806. PMID:9671489 doi:10.1128/MCB.18.8.4793
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