Structural highlights
Function
ZNT3_HUMAN Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain.[1] [2] [3]
References
- ↑ Falcón-Pérez JM, Dell'Angelica EC. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007 Apr 15;313(7):1473-83. PMID:17349999 doi:10.1016/j.yexcr.2007.02.006
- ↑ Salazar G, Falcon-Perez JM, Harrison R, Faundez V. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. PLoS One. 2009 Jun 12;4(6):e5896. PMID:19521526 doi:10.1371/journal.pone.0005896
- ↑ Hildebrand MS, Phillips AM, Mullen SA, Adlard PA, Hardies K, Damiano JA, Wimmer V, Bellows ST, McMahon JM, Burgess R, Hendrickx R, Weckhuysen S, Suls A, De Jonghe P, Scheffer IE, Petrou S, Berkovic SF, Reid CA. Loss of synaptic Zn2+ transporter function increases risk of febrile seizures. Sci Rep. 2015 Dec 9;5:17816. PMID:26647834 doi:10.1038/srep17816
