9jqg
Crystal structure of rice DWARF14 in complex with Cyclo(L-Leu-L-Pro)
Structural highlights
FunctionD14_ORYSJ Involved in strigolactone signaling pathway. May function downstream of strigolactone synthesis, as a component of hormone signaling or as an enzyme that participates in the conversion of strigolactones to the bioactive form. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.[1] [2] Publication Abstract from PubMedRice tillering is an important agronomic trait regulated by plant genetic and environmental factors. However, the role and mechanism of the root microbiota in modulating rice tillering have not been explored. Here, we examined the root microbiota composition and tiller numbers of 182 genome-sequenced rice varieties grown under field conditions and uncovered a significant correlation between root microbiota composition and rice tiller number. Using cultivated bacterial isolates, we demonstrated that various members of the root microbiota can regulate rice tillering in both laboratory and field conditions. Genetic, biochemical, and structural analyses revealed that cyclo(Leu-Pro), produced by the tiller-inhibiting bacterium Exiguobacterium R2567, activates the rice strigolactone (SL) signaling pathway by binding to the SL receptor OsD14, thus regulating tillering. The present work provides insight into how the root microbiota regulates key agronomic traits and offers a promising strategy for optimizing crop growth by harnessing the root microbiota in sustainable agriculture. Root microbiota regulates tiller number in rice.,Zhang J, Wang B, Xu H, Liu W, Yu J, Wang Q, Yu H, Wei JW, Dai R, Zhou J, He Y, Zou D, Yang J, Ban X, Hu Q, Meng X, Liu YX, Wang B, Hu B, Wang M, Xin P, Chu J, Li C, Garrido-Oter R, Yu P, van Dijk ADJ, Dong L, Bouwmeester H, Gao S, Huang A, Chu C, Li J, Bai Y Cell. 2025 Apr 16:S0092-8674(25)00351-4. doi: 10.1016/j.cell.2025.03.033. PMID:40267905[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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