9jvq

Yeast Mitochondrial PORIN complex

spinqualitylabelsall models 9jvq, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9jvq is a 6 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.2Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function VDAC1_YEAST Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane (PubMed:9435273). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:9435273). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:9435273). Is the major permeability factor of the mitochondrial outer membrane (PubMed:9435273). Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids.

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