Structural highlights
9k95 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
|
| Method: | Electron Microscopy, Resolution 2.9Å |
| Ligands: | A1D6X, BMA, CLR, NAG, PC1 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
NICA_HUMAN Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.
Function
NICA_HUMAN Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
