9kk3

Solution structure of kappa-conotoxin RIIIK

spinqualitylabelsall models 9kk3 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9kk3 is a 1 chain structure with sequence from Conus radiatus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 10 models Ligands: HYP, NH2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CM3K_CONRA Kappa-conotoxins inhibits voltage-gated potassium channels (Kv). This synthetic toxin reversibly inhibits the insect potassium channel Shaker K+, the teleost homolog TSha1 and the mammalian Kv1.2/KCNA2 channel. Interacts with the pore region of the insect channel, in a state-dependent manner. Causes seizure when intracerebrovascularly injected into mice. Is also toxic when intrathecally injected into mice, but shows no visible effects by intraperitoneal injection. Shows protective effects on cardiac tissue when administered after an ischemic event.

Proteopedia Page Contributors and Editors (what is this?)

OCA