Structural highlights
Function
NPPPS_MYCTU Catalyzes the sequential condensations of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP), with E,E-FPP to yield geranylgeranyl diphosphate (GGPP) and with GGPP to yield nonaprenyl diphosphate (PubMed:23091471, PubMed:30301210, PubMed:32495977). May also have weak activity with dimethylallyl diphosphate (DMAPP) (PubMed:23091471).[1] [2] [3]
References
- ↑ Mann FM, Xu M, Davenport EK, Peters RJ. Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria. Front Microbiol. 2012 Oct 12;3:368. PMID:23091471 doi:10.3389/fmicb.2012.00368
- ↑ Nagel R, Thomas JA, Adekunle FA, Mann FM, Peters RJ. Arginine in the FARM and SARM: A Role in Chain-Length Determination for Arginine in the Aspartate-Rich Motifs of Isoprenyl Diphosphate Synthases from Mycobacterium tuberculosis. Molecules. 2018 Oct 6;23(10):2546. PMID:30301210 doi:10.3390/molecules23102546
- ↑ Abe T, Ozaki S, Ueda D, Sato T. Insight into Isoprenoid Biosynthesis by Functional Analysis of Isoprenyl Diphosphate Synthases from Mycobacterium vanbaalenii and Mycobacterium tuberculosis. Chembiochem. 2020 Oct 15;21(20):2931-2938. PMID:32495977 doi:10.1002/cbic.202000235
