9l0d

Cryo-EM structure of the human MON1A/CCZ1/C18orf8 complex

spinqualitylabelsall models 9l0d, resolution 3.41Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9l0d is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.41Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MON1A_HUMAN Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).[UniProtKB:Q6PDG8]

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