9la9

Munc13-4-Rab27a complex with GppNHp

spinqualitylabelsall models 9la9, resolution 4.38Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9la9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.38Å Ligands: GNP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease UN13D_HUMAN Familial hemophagocytic lymphohistiocytosis. The disease is caused by variants affecting the gene represented in this entry. Function UN13D_HUMAN Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

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