9mbo

Focused refinement of RPN1 and the C-terminal helix of midnolin in the substrate-engaged human 26S proteasome

spinqualitylabelsall models 9mbo, resolution 2.83Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9mbo is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.83Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MIDN_HUMAN Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.[UniProtKB:D4AE48][UniProtKB:Q3TPJ7]

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