9nau

CryoEM structure of capsid from human astrovirus 1 in complex with human neonatal Fc receptor

spinqualitylabelsall models 9nau, resolution 2.77Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9nau is a 3 chain structure with sequence from Human astrovirus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.77Å Ligands: K Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CAPSD_HASV1 The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the immature VP70 virion.[UniProtKB:Q9IFX1] The immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry (By similarity). During maturation, VP70 undergoes a loss of 60 peripentonal spikes, which likely plays an important role in viral infectivity (By similarity).[UniProtKB:Q9IFX1] Self-assembles to form an icosahedral capsid with a T=3 symmetry, about 43 nm in diameter (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707). VP25 and VP27 Forms the spikes at the surface of the virion (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707). Plays a role in the attachment to target host cell (Probable). This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).[UniProtKB:Q9IFX1] VP25 and VP27 Forms the spikes at the surface of the virion (PubMed:26656707). This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:26656707). Plays a role in the attachment to target host cell (PubMed:33396308). This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).[UniProtKB:Q9IFX1]

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