| Structural highlights
Function
MATRX_NIPAV Plays a crucial role in virion assembly and budding. Forms a shell at the inner face of the plasma membrane (PubMed:17005661, PubMed:17204159, PubMed:19000317). Transits through the host nucleus before gaining the functional ability to localize and bud from the plasma membrane (PubMed:21085610). Mediates together with fusion protein the incorporation of the glycoprotein to the viral particles (PubMed:28250132). Also participates in the inhibition of the host interferon type I antiviral response by interacting with and thereby inhibiting host TRIM6 (PubMed:27622505).[1] [2] [3] [4] [5] [6]
References
- ↑ Ciancanelli MJ, Basler CF. Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. J Virol. 2006 Dec;80(24):12070-8. PMID:17005661 doi:10.1128/JVI.01743-06
- ↑ Patch JR, Crameri G, Wang LF, Eaton BT, Broder CC. Quantitative analysis of Nipah virus proteins released as virus-like particles reveals central role for the matrix protein. Virol J. 2007 Jan 4;4:1. PMID:17204159 doi:10.1186/1743-422X-4-1
- ↑ Patch JR, Han Z, McCarthy SE, Yan L, Wang LF, Harty RN, Broder CC. The YPLGVG sequence of the Nipah virus matrix protein is required for budding. Virol J. 2008 Nov 10;5:137. PMID:19000317 doi:10.1186/1743-422X-5-137
- ↑ Wang YE, Park A, Lake M, Pentecost M, Torres B, Yun TE, Wolf MC, Holbrook MR, Freiberg AN, Lee B. Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding. PLoS Pathog. 2010 Nov 11;6(11):e1001186. PMID:21085610 doi:10.1371/journal.ppat.1001186
- ↑ Bharaj P, Wang YE, Dawes BE, Yun TE, Park A, Yen B, Basler CF, Freiberg AN, Lee B, Rajsbaum R. The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response. PLoS Pathog. 2016 Sep 13;12(9):e1005880. PMID:27622505 doi:10.1371/journal.ppat.1005880
- ↑ Johnston GP, Contreras EM, Dabundo J, Henderson BA, Matz KM, Ortega V, Ramirez A, Park A, Aguilar HC. Cytoplasmic Motifs in the Nipah Virus Fusion Protein Modulate Virus Particle Assembly and Egress. J Virol. 2017 Apr 28;91(10):e02150-16. PMID:28250132 doi:10.1128/JVI.02150-16
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