9o4g
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Cryo-EM structure of the CHSY3-CHPF1 chondroitin synthase heterodimer
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Structural highlights
FunctionCHSS3_HUMAN Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1.[1] References
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This page was last modified 07:51, 4 March 2026.