| Structural highlights
Disease
MPC1_HUMAN Mitochondrial pyruvate carrier deficiency. The disease is caused by variants affecting the gene represented in this entry.
Function
MALE_ECOLI Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.MPC1_HUMAN Mediates the uptake of pyruvate into mitochondria.[1] [2] [3]
References
- ↑ Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012 Jul 6;337(6090):96-100. PMID:22628558 doi:10.1126/science.1218099
- ↑ Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou JC. Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect. Mol Cell. 2015 Aug 6;59(3):491-501. PMID:26253029 doi:10.1016/j.molcel.2015.06.035
- ↑ Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou JC. MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. J Biol Chem. 2016 Aug 5;291(32):16448-61. PMID:27317664 doi:10.1074/jbc.M116.733840
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