9oyo

Structure of R15L D10-NT amyloid fibrils

spinqualitylabelsall models 9oyo, resolution 3.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9oyo is a 18 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.15Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease CHC10_HUMAN Frontotemporal dementia with motor neuron disease;Autosomal dominant mitochondrial myopathy with exercise intolerance;Amyotrophic lateral sclerosis;Lower motor neuron syndrome with late-adult onset. The disease is caused by variants affecting the gene represented in this entry. The pathological events leading to disease involve fragmentation of the mitochondrial network, mitochondrial ultrastructural abnormalities including loss, disorganization and dilatation of cristae, and mitochondrial dysfunction associated with respiratory chain deficiency (PubMed:24934289). The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Function CHC10_HUMAN May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.

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