9pn4

Crystal structure of a three finger toxin from snake venom

spinqualitylabelsall models 9pn4, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9pn4 is a 4 chain structure with sequence from Ophiophagus hannah. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.1Å Ligands: EDO, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function 3SX1_OPHHA This toxin binds and inhibits rat muscle adult alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE (IC(50)=3.1 uM) and fetal alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND (IC(50)=5.6 uM) nicotinic acetylcholine receptors (nAChR) (PubMed:26448325). Shows a very low inhibition on rat neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=50.2 uM) nAChR (PubMed:26448325). Binds to the acetylcholine-binding pocket and acts as a competitive antagonist (PubMed:26448325). Does not inhibit human glycine receptor (homopentamer composed of alpha-1 subunits, GLRA1), but seems to potentiate it (about 2-fold increased activity) (PubMed:26448325).

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