9qdt

Cytochrome c peroxidase YhjA

spinqualitylabelsall models 9qdt, resolution 2.57Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9qdt is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.572Å Ligands: CA, CL, EPE, HEC, HEM, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CCP_ECOLI Cytochrome peroxidase that enables anaerobic respiration with H(2)O(2) as a terminal electron acceptor (PubMed:28696311). It receives electrons from the quinol pool (PubMed:28696311, PubMed:29550214). Menaquinol is probably the electron donor in vivo (PubMed:28696311, PubMed:29550214). It can use menadiol (a menaquinol analog), hydroquinone, duroquinol and the artificial electron donor ABTS(2-) in vitro, but only menadiol and hydroquinone can efficiently transfer electrons to Ccp, maintaining the catalytic activity of the enzyme (PubMed:29550214). It enables E.coli to grow on a nonfermentable carbon source when H(2)O(2) is supplied (PubMed:28696311). Plays a role in the peroxide stress response under anaerobic conditions (PubMed:17464064). However, it does not degrade H(2)O(2) quickly enough to lower the periplasmic H(2)O(2) level below that of the surrounding medium and protect the cell from its toxic effects (PubMed:28696311).

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