9qzk

SadB of Pseudomonas aeruginosa

spinqualitylabelsall models 9qzk, resolution 3.16Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9qzk is a 4 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.16Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9HTL2_PSEAE Publication Abstract from PubMed The ability of bacteria to commit to surface colonization and biofilm formation is a highly regulated process. In this study, we characterized the activity and structure of SadB, initially identified as a key regulator in the transition from reversible to irreversible surface attachment. Our results show that SadB acts as an adaptor protein that tightly regulates the master regulator AmrZ at the post-translational level. SadB directly binds to the C-terminal domain of AmrZ, leading to its rapid degradation, primarily by the Lon protease. Structural analysis suggests that SadB does not directly interact with small molecules upon signal transduction, differing from previous findings in Pseudomonas fluorescens. Instead, the SadB structure supports its role in mediating protein-protein interactions, establishing it as a major checkpoint for biofilm commitment. SadB, a mediator of AmrZ proteolysis and biofilm development in Pseudomonas aeruginosa.,Ben-David Y, Sporny M, Brochin Y, Piscon B, Roth S, Zander I, Nisani M, Shoshani S, Yaron O, Karako-Lampert S, Lebenthal-Loinger I, Danielli A, Opatowsky Y, Banin E NPJ Biofilms Microbiomes. 2025 May 13;11(1):77. doi: 10.1038/s41522-025-00710-0. PMID:40360526 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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