Structural highlights
Function
PCSB_STRP2 Peptidoglycan-hydrolase activity (PubMed:24804636). Required in maintaining normal growth and cellular morphology (PubMed:19270090, PubMed:22006325). Involved in splitting of the septum during cell division (By similarity).[UniProtKB:Q8DMY4][1] [2] [3]
References
- ↑ Barendt SM, Land AD, Sham LT, Ng WL, Tsui HC, Arnold RJ, Winkler ME. Influences of capsule on cell shape and chain formation of wild-type and pcsB mutants of serotype 2 Streptococcus pneumoniae. J Bacteriol. 2009 May;191(9):3024-40. PMID:19270090 doi:10.1128/JB.01505-08
- ↑ Sham LT, Barendt SM, Kopecky KE, Winkler ME. Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):E1061-9. doi: , 10.1073/pnas.1108323108. Epub 2011 Oct 17. PMID:22006325 doi:https://dx.doi.org/10.1073/pnas.1108323108
- ↑ Bartual SG, Straume D, Stamsas GA, Munoz IG, Alfonso C, Martinez-Ripoll M, Havarstein LS, Hermoso JA. Structural basis of PcsB-mediated cell separation in Streptococcus pneumoniae. Nat Commun. 2014 May 8;5:3842. doi: 10.1038/ncomms4842. PMID:24804636 doi:https://dx.doi.org/10.1038/ncomms4842
