Structural highlights
9rhw is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
|
| Method: | X-ray diffraction, Resolution 1.25Å |
| Ligands: | 7WW, DMS, EDO, EOH, MPD, PO4 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
MGLL_MYCTU Involved in the hydrolysis of exogenous host lipids during chronic infection. Catalyzes the hydrolysis of both monoacylglycerols (MAG) and diacylglycerols (DAG). It hydrolyzes 2-MAG, 1-3-MAG and MAG with short, medium and long chain fatty acids such as 1-monobutyroyl-rac-glycerol (MC4), 1-mono-octanoyl-rac-glycerol (MC8), 1-monodecanoyl-rac-glycerol (MC10), 1-monolauroyl-rac-glycerol (MC12), 1-monomyristoyl-rac-glycerol (MC14) and 1-mono-oleyl-rac-glycerol (MC18:1) (PubMed:17784850). Also able to hydrolyze DAG with short (DiC6) and medium (DiC10) fatty acid chains, but not whith a longest chain fatty acids (PubMed:17784850). Can also hydrolyze vinyl laurate (VC12), vinyl butyrate (VC4) and vinyl propionate (VC3) (PubMed:17784850).[1] [2]
References
- ↑ Cotes K, Dhouib R, Douchet I, Chahinian H, de Caro A, Carriere F, Canaan S. Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids. Biochem J. 2007 Dec 15;408(3):417-27. doi: 10.1042/BJ20070745. PMID:17784850 doi:https://dx.doi.org/10.1042/BJ20070745
- ↑ Saravanan P, Dubey VK, Patra S. Potential selective inhibitors against Rv0183 of Mycobacterium tuberculosis targeting host lipid metabolism. Chem Biol Drug Des. 2012 Jun;79(6):1056-62. doi:, 10.1111/j.1747-0285.2012.01373.x. Epub 2012 Apr 17. PMID:22405030 doi:https://dx.doi.org/10.1111/j.1747-0285.2012.01373.x
